How do you make aspirin chemically?

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To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched with the addition of water.

What materials are used to make aspirin?

In particular, the production of hard aspirin tablets requires only four ingredients: the active ingredient (acetylsalicylic acid), corn starch, water, and a lubricant.

What type of reaction is used to make aspirin?

The synthesis of aspirin is known in organic chemistry as an esterification reaction. This is a substitution reaction in which an alcohol (the –OH group in salicylic acid) reacts with acetic anhydride to form an ester, aspirin.

How is aspirin made from benzene?

In fact, the starting material for the chemical synthesis of aspirin is benzene, derived from petroleum. This is then converted to phenol which in turn is converted to salicylic acid which is then converted to acetylsalicylic acid or ASA, which we know as aspirin.

Why is sulfuric acid used in aspirin synthesis?

The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid. Aim: To prepare aspirin from salicylic acid.

How is aspirin purified in a lab?

The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2). After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.

What is the industrial method for making aspirin?

Aspirin is the most widely sold over-the-counter drug. The production process involves the reaction of Salicylic acid and acetic anhydride in glass lined vessels. The liquid produced is pumped to a crystallizer, where it is cooled down to start the crystallization to Aspirin.

How do you make aspirin in a school lab?

SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H2SO4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.

How do you make homemade aspirin?

Why is salicylic acid converted to aspirin?

In folk medicines willow bark trees were used as headache remedies and as other tonics too. But these create irritations in the stomach therefore, nowadays salicylic acid is administered in the form of aspirin which is less irritating to the stomach.

Can you make your own aspirin?

It’s very simple: Just drop uncoated aspirin into a glass of club soda or seltzer water. It will take a couple of minutes to dissolve with a bit of stirring. You can add a half teaspoon of baking soda to 8 ounces of sparkling water if you want to buffer the aspirin. For flavor, squeeze in the juice from a lemon wedge.

Where does aspirin come from?

History of aspirin It comes from Spiraea, a biological genus of shrubs that includes natural sources of the drug’s key ingredient: salicylic acid. This acid, resembling what’s in modern-day aspirin, can be found in jasmine, beans, peas, clover and certain grasses and trees.

How do you make aspirin without acetic anhydride?

It is possible to produce aspirin by reacting salicylic acid with acetic acid & sodium acetate by heating one and half hr. & pouring the reaction mixture in ice-water mixture to get solid aspirin. I think the obvious answer here would be the use of acetyl chloride with some DMAP and base.

Why is phosphoric acid used to make aspirin?

Phosphoric acid acts as a catalyst to accelerate the reaction. (Catalyst is a substance that can be added to a reaction and helps speed up the reaction without getting caught in the process.

Why do you wash aspirin with cold water?

The aspirin crystals are collected on a Buchner funnel and washed with additional ice cold distilled water. Acetic anhydride decomposes to water soluble acetic acid. Aspirin has a low solubility in cold water, so excess reactants could be washed away with cold water.

What is the basic principle in the preparation of aspirin?

Principle : Synthesis of Aspirin from salicylic acid occurs by acetylating process in acidic medium. Salicylic acid interacts with acetic anhydrides in presence of few drops of conc. sulphuric acid to produce aspirin and a molecule of acetic acid.

Why is ethanol used to purify aspirin?

Ethanol has been chosen as the solvent because the polar nature of the hydroxyl group causes ethanol to dissolve many ionic compounds, moreover the ethanol molecule also has a non-polar end, and it will also dissolve non-polar substances. While cooling, crystallization takes place.

How is aspirin made and tested in industry?

Because today’s aspirin is mass produced in tablet form, Spectrophotometers are a reliable and economical way to keep the purity of Aspirin consistent throughout the manufacturing process. The purity and amount of acetylsalicylic acid in aspirin can be measured using a Visual Spectrophotometer.

What happens when aspirin dissolves in water?

Aspirin is a pain reliever and fever reducer, but if it’s allowed to react with water then it can undergo hydrolysis, forming salicylic acid and acetic acid, which is no longer effective. This reaction can occur under acidic or basic conditions.

Is aspirin made from willow bark?

It is a common misconception that aspirin is found in the bark of the willow tree. A related compound called salicin does indeed occur in willow bark, thereby explaining the use of the bark as a medication since the time of Hippocrates.

Why does aspirin smell like vinegar?

When acetylsalicylic acid ages, it may decompose and return to salicylic acid and acetic acid. If you have a very old bottle of aspirin around the house, open it and take a sniff. It may smell like vinegar, because vinegar is dilute acetic acid.

What is another name for aspirin?

Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects.

Can aspirin be recrystallized using hot water?

But if boiling water is added to aspirin for recrystallization, it can worsen the conditions. Because boiling water can react with aspirin (acetylsalicylic acid) and can revert the chemical reaction into salicylic acid and acetic acid. This prevents the recrystallization process.

What is natural aspirin?

What is willow bark? Willow bark, the bark of several varieties of willow tree, has been used for centuries as a pain reliever. The active ingredient in the medicine made from willow bark is called salicin.

Is there a natural alternative to aspirin?

Like aspirin, ginger works as a blood thinner which can prevent the formation of clots that can lead to heart attack or stroke. Ginger also reduces inflammation in the same way as aspirin by blocking COX-2 — the enzyme that promotes inflammation.

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