What does EDC stand for in chemistry?


Sharing is Caring


The chemical compound 1,2-dichloroethane, commonly known as ethylene dichloride (EDC), is a chlorinated hydrocarbon, mainly used to produce vinyl chloride monomer (VCM, chloroethene), the major precursor for PVC production.

What is EDC NHS chemistry?

EDC (also called EDAC) is 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide hydrochloride, MW 191.70. DCC is N’, N’-dicyclohexyl carbodiimide, MW 206.32. Carbodiimide conjugation, as with CDI-mediated conjugation, works by activating carboxyl groups for direct reaction with primary amines via amide bond formation.

What is EDC crosslinking?

EDC is the most popular zero-length crosslinker for biochemical conjugations because it can efficiently form conjugates between two protein molecules, between a protein and a peptide, and between proteins and oligonucleotides, and with small molecules.

What is the range of EDC?

In other words, how many notes do Coda EDC flutes play? Coda plays two chromatic octaves, from C5 to C7 (plus a few notes below C5 that you can access using a special technique).

What is EDC reagent?

EDC hydrochloride is a coupling reagent. Classified as a carbodiimide, EDC hydrochloride is carboxyl activating and water soluble. EDC hydrochloride is used for amide bond formation in oligonucleotides and tetraazamacrocycles.

What can you do identify if a product has an EDC?

Read the labels. On plastic bottles, a #1, #2, or #4 in the recycling sign means that the product is free of BPA, a still commonly-used EDC. Shower curtains, raincoats, flooring, and outdoor furniture will be similarly labeled for PVCs, as will canned food with BPA-free liners.

What does NHS and EDC do?

N-hydroxysuccinimide (NHS) or its water-soluble analog (Sulfo-NHS) is often included in EDC coupling protocols to improve efficiency or create dry-stable (amine-reactive) intermediates.

What is EDC HCL?

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.

What is the chemical name of NHS?

N-Hydroxysuccinimide (NHS) is an organic compound with the formula (CH2CO)2NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis.

What is EDC NHS coupling?

EDC/NHS coupling chemistry is commonly used to alter the surface chemistry of NPs with biological molecules to reduce their toxicity [31], [32]. EDC is a water-soluble cross-linker agent, which forms amide bonds between carboxyl and amine groups.

What is the role of carbodiimide in the synthesis of amide?

In organic synthesis, compounds containing the carbodiimide functionality are used as dehydration agents. Specifically they are often used to convert carboxylic acids to amides or esters. Additives, such as N-hydroxybenzotriazole or N-hydroxysuccinimide, are often added to increase yields and decrease side reactions.

How is EDC made?

EDC is made by the direct chlorination or oxychlorination of ethylene. Most EDC plants are integrated with VCM plants. The VCM process generates considerable quantities of hydrogen chloride (HCl), which is then recycled in the oxychlorination process to generate more EDC.

Is EDC water sensitive?

Handling, Storage, and Precautions: EDC is moisture-sensitive; store under N2 in a cool dry place.

What is EDC in water?

Endocrine disrupting compounds (EDCs) are an environmental contaminant of growing concern, which undermine the safety of drinking water. The potential health issues of EDCs are not fully understood yet due to there being relatively scarce research on their exposure and associated risks via drinking water consumption.

Is EDC hygroscopic?

NOTE: EDC is highly hygroscopic; failure to allow to equilibrate may lead to poor cross linking.

Is DMAP a base?

For example, the reaction runs through a base-catalyzed reaction pathway in the case of a phenol. In this case, DMAP acts as a base and deprotonates the phenol, and the resulting phenolate ion adds to the anhydride.

How does HOBt prevent racemization?

Adding HOBt, 6-Cl-HOBt or HOAt suppresses the racemization. Histidine and cysteine are especially prone to racemization. Protecting the pi imidazole nitrogen in the histidine side-chain with the methoxybenzyl group greatly reduces racemization.

How can we prevent EDC chemicals?

  1. Wash your hands.
  2. Dust and vacuum often.
  3. Turn up your nose at fragrances.
  4. Think twice about plastics.
  5. Say “no can do” to cans.
  6. Watch what you eat.
  7. Filter your tap water.
  8. Rethink kids’ cosmetics.

How do EDCs work?

EDCs, by occupying the same receptor sites in the target cells as the natural hormone would do, can mimic the effect of a hormone or block its action. Other ways in which EDCs can work โ€“ such as disrupting hormone production, transport or breakdown โ€“ have been shown to be equally important.

How do we get exposed to EDC?

People are exposed to these EDCs when they leach into foods or are released when containers are microwaved. Many companies have voluntarily removed phthalates from their products and advertise them as “phthalate-free”.

Is NHS an ester?

How are NHS and Sulfo-NHS used? These compounds are used to modify a carboxyl group to form an amine-reactive ester.

How stable is NHS ester?

In relation to other active compounds, NHS esters are relatively stable and can be stored for months under dry conditions. However, in practice, hydrolysis of NHS esters is a frequent reason for suboptimal conjugation results or even a complete failure of the respective derivatization reactions.

Is NHS water soluble?

Both NHS and Sulfo-NHS are soluble in aqueous and organic solvents. Activation with NHS, however, decreases water- solubility of the modified carboxylate molecule, while activation with Sulfo-NHS preserves or increases water-solubility of the modified molecule, by virtue of the charged sulfonate group.

How do you conjugate two proteins?

Generally, Protein protein conjugation is carried out by using crosslinkers. Crosslinking is the process of chemically joining two or more molecules by a covalent bond.

What is Amine Coupling?

Amine coupling is one of the most common methods to immobilize a protein or a small molecule containing primary amine group through a covalent bond on biosensors used in QCM(Quartz Crystal Microbalance), SPR(Surface Plasmon Resonance) or an electrode analysis.

Craving More Content?

ScienceOxygen