Alginate is a naturally occurring anionic polymer typically obtained from brown seaweed, and has been extensively investigated and used for many biomedical applications, due to its biocompatibility, low toxicity, relatively low cost, and mild gelation by addition of divalent cations such as Ca2+ .
What is the purpose of sodium alginate biology?
Applications of sodium alginate Alginate is used in many foods and biomedical applications, due to its biocompatibility, low toxicity, relatively low cost, and mild gelation . In the food industry, alginate is used as a thickening agent, gelling agent, emulsifier, stabilizer, texture-improver.
What properties does alginate have?
Alginates have several properties such as film-forming ability, pH responsiveness, and gelling, hydrophilicity, biocompatibility, biodegradability, non-toxic, processability and ionic crosslinking.
Is alginate bioactive?
The study suggests that microspheres made of a composite of bioactive inorganic materials and alginate have a bioactivity and degradation profile which greatly improves their drug delivery capacity, thus enhancing their potential applications as bioactive filler materials for bone tissue regeneration.
What are the advantages of alginate?
The wound dressings by using alginate based materials have many advantages in comparison to conventional gauze dressing because the wound exudates can be easily evaporated with preventing the entry of pathogenic bacteria and provides a moist environment in the wound areas and accelerates wound healing.
What is the composition of alginate?
The alginate materials were mainly composed of silicon (Si) by weight (C—81.59%, H—79.89%, O—78.87%, H5—77.95%, JP—66.88%, wt). The filler fractions in volume (vt) were as follows: H5—84.85%, JP—74.76%, H—70.03%, O—68.31%, and C—56.10%.
What is the biological source of sodium alginate?
Sodium alginate is extracted from brown seaweeds (Phaeophyceae). The alginic acid, the free acid form of alginate, is extracted from the seaweed in alkaline conditions, then precipitated and ion-exchanged (e.g. with potassium).
How do alginates work?
Many of the common antacids also include alginates. Most alginates work by forming a gel which floats on top of the stomach contents. The gel acts as a protective barrier, preventing stomach acid from irritating the oesophagus.
What are the advantages of sodium alginate method of immobilization?
… The amylase was successfully immobilized by entrapping in alginate. These results improve the finding that told the increasing of the concentration of sodium alginate prevents the entrance of substrate into the beads that directed to the lower immobilization efficacy (Dey et al.
Is alginate a hydrocolloid?
Kendall™ alginate hydrocolloid dressings are sterile wound dressings designed for use on light to moderately exudating wounds. These dressings help provide an optimal moist wound healing environment. The alginate formulation provides greater absorbency helping to reduce the number of dressing changes.
Is alginate hydrophilic or hydrophobic?
2.2 Alginates Sodium alginate is a natural hydrophilic polysaccharide derived isolated from marine brown algae. It has been widely investigated in the field of drug delivery due to its biocompatible and biodegradable nature.
Is alginate water soluble?
Alginic acid and calcium alginate are water-insoluble. All the alginate salts are insoluble to fats & oils and organic solvents.
Is alginate biodegradable in humans?
Alginate is a natural polysaccharide exhibiting excellent biocompatibility and biodegradability, having many different applications in the field of biomedicine.
Is alginate a protein?
Alginate is a bioadhesive polymer which can be advantageous for the site specific delivery to mucosal tissues. All of these properties, in addition to the nonimmunogenicity of alginate, have led to an increased use of this polymer as a protein delivery system.
How does alginate degrade?
Alginate gel degradation occurs via a slow and unpredictable dissolution process in vivo, mainly due to the sensitivity of the gels towards calcium chelating compounds, (e.g., phosphate, citrate, and lactate) . One previously reported approach to control alginate gel degradation involved partial periodate oxidation.
What is a disadvantage of alginate?
Alginate Disadvantages: poor dimensional stability, poor tear strength, distortion if unsupported, requires good mixing otherwise air bubbles, minimum 3mm thickness required.
What are the two types of alginate?
The alginates available on the market can be of two types: fast setting (hardening time of 1–2 min) or normal setting (setting time between 2–5 min).
What is the difference between alginate and sodium alginate?
Sodium alginate, produced as described above, is the main form of alginate in use. Smaller quantities of alginic acid and the calcium, ammonium and potassium salts, and an ester, propylene glycol alginate, are also produced.
What organism makes alginate?
Alginates were first isolated from brown seaweeds in the 1880s, and its commercial production begun in the early 20th century. Alginate can be produced by various genera of brown seaweed and two genera of bacteria, Pseudomonas and Azotobacter.
Is alginate the same as calcium alginate?
Calcium alginate is the insoluble form of alginate with high swelling capacity. It can be woven to produce pliable patches or ribbons for filling cavity or tunneling wounds.
Why is alginate used in ice cream?
It is commonly used as a thickener in foods such as ice cream and fruit-filled snacks. For the demonstration, a 2% solution of sodium alginate is poured into a 1% solution of calcium chloride. Nontoxic calcium alginate “worms” form due to crosslinking of the polymer.
Why does sodium alginate dissolve in water?
The negatively charged carboxyl groups in alginates cause the straight alginate chains to repel each other and this results in a stable aqueous solution. This aqueous solution has smooth flow properties with Newtonian behavior. ALGIN is a water-soluble polysaccharide and gives a viscous colloidal solution.
What can I substitute for sodium alginate?
Natural rubber, such as hexane, or other natural gums, such as gaur gum or xantham gum, can be substituted for sodium alginate. Starch thickeners may also be substituted, but they may react to the dye and change the color results.
What does alginate do for a wound?
Alginate dressings can absorb wound fluid in the dry form and form gels that can provide a dry wound with a physiologically moist environment and minimize bacterial infections, thereby promoting rapid re-epithelialization and granulation tissue formation.
Why are alginate dressings not suitable for dry wounds?
Although alginate dressings generally become moistened within the wound, they should not be used in very dry wounds because a burning sensation may be experienced as fluid is ‘drawn’ from the wound bed as a result of the hydrophilic effect.