What is ETS gene?

The Ets Gene Family Ets proteins are transcription factors that share a conserved winged helix-turn-helix DNA binding domain (ETS domain), recognizing unique DNA sequences containing GGAA/T (Ets binding sites, EBS). Several Ets proteins also contain the Pointed (PNT) domain, important for protein–protein interaction.

What is the main ETS function?

The Ets transcription factor family is involved in a variety of mammalian developmental processes at the cellular, tissue and organ levels. They are implicated in cellular proliferation, differentiation, migration, apoptosis and cell – cell interactions.

What is ERG in biology?

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG’s oncogenic potential is well known because of its involvement in Ewing’s sarcoma and leukaemia.

Do all transcription factors have a DNA binding domain?

Abstract. Transcription factors are modular in nature in all organisms. In general, they have a DNA binding domain, one or more transcription activation and/or repressor domain, and often a dimerization domain. In many cases, transcription factors also have other protein-protein interaction domain(s).

What is Ets binding site?

Structure. All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence.

What is est in bioinformatics?

Abstract. Expressed sequence tags (ESTs) are fragments of mRNA sequences derived through single sequencing reactions performed on randomly selected clones from cDNA libraries. To date, over 45 million ESTs have been generated from over 1400 different species of eukaryotes.

What is the difference between ERG and EOG in biology?

Explanation: ERGs are evaluated using an electrode kept in touch with the middle eye coat or cornea. The electrical activity of the retina forms at the cornea by electrodes. EOG is also known as an electrooculogram (EOG). The test evaluates the resting electrical potential between the cornea and Bruch’s membrane.

What is ERG medical term?

Definition. The electroretinogram (ERG) is a diagnostic test that measures the electrical activity of the retina in response to a light stimulus. The ERG arises from currents generated directly by retinal neurons in combination with contributions from retinal glia.

How is an ERG test performed?

In this test, the rods, cones and light sensitive cells of the eyes are examined. During the test, an electrode is placed on the cornea (the front of the eye) to measure your retinal cells’ electrical response to light. An ERG is useful in evaluating inherited (hereditary) and acquired disorders of the retina.

What are the 3 transcription factors?

Many transcription factors are either tumor suppressors or oncogenes, and, thus, mutations or aberrant regulation of them is associated with cancer. Three groups of transcription factors are known to be important in human cancer: (1) the NF-kappaB and AP-1 families, (2) the STAT family and (3) the steroid receptors.

Why are transcription factors so important?

Transcription factors are proteins that bind to the upstream regulatory elements of genes in the promoter and enhancer regions of DNA and stimulate or inhibit gene expression and protein synthesis. They play critical roles in embryogenesis and development.

How many transcription factors are there in humans?

According to recent data, the human genome encodes about 1500 regulatory sequence-specific DNA-binding factors (transcription factors, TFs) [7–9].

What is EST in Human Genome Project?

The Expressed Sequence Tag (EST) division of GenBank, dbEST, is a large repository of the data being generated by human genome sequencing centers. ESTs are short, single pass cDNA sequences generated from randomly selected library clones.

What is cDNA in biology?

Complementary DNA (cDNA) is a DNA copy of a messenger RNA (mRNA) molecule produced by reverse transcriptase, a DNA polymerase that can use either DNA or RNA as a template. From: Encyclopedia of Genetics, 2001.

What are SNP markers?

Most commonly, SNPs are found in the DNA between genes. They can act as biological markers, helping scientists locate genes that are associated with disease. When SNPs occur within a gene or in a regulatory region near a gene, they may play a more direct role in disease by affecting the gene’s function.

What is EMG and EOG?

In a nutshell, EMG is essentially electrical “noise” generated by facial muscle activity near the electrode. EOG is electrical noise generated by eye movement. Some might consider EMG and EOG the evil cousins of EEG.

What is EOG and ERG?

The electroretinogram (ERG) and electrooculogram (EOG) are electrophysiological tests employed in ophthalmology to diagnose degeneration or injury to the outer half of the retina, including the rods and cones of the visual system.

What do the EEG EMG and EOG measure?

An electrocardiogram (ECG or EKG), electroencephalogram (EEG), electromyogram (EMG) and electrooculogram (EOG) all measure biopotentials, the electrical output of human activity.

How long is an ERG test?

The duration of the test is approximately 45 minutes: the patient must spend 20 minutes adapting to the dark and then look inside a dome, where light flashes stimulate the retina.

What is a ERG in social studies?

They are increasingly relevant today as gender issues, questions of personal identity and politics affect everyone. So what are Employee Resource Groups (ERGs)? Employee Resource Groups are voluntary, employee-led groups whose aim is to foster a diverse, inclusive workplace aligned with the organizations they serve.

What is full field ERG?

The full-field electroretinogram (ffERG) is an ophthalmologic test that provides non-invasive objective quantitative measures of the electrical activity in the retina. The ffERG represents an electrical response from the retina to a flash of light and measures global retinal function.

What does an abnormal ERG mean?

What does an abnormal ERG mean? An abnormal ERG result suggests abnormal function of the retina which may be caused by a number of diseases of the retina. The results of the ERG will be discussed with your doctor.

Does cone dystrophy cause blindness?

In the progressive form of cone dystrophy, vision continues to deteriorate over time. In many cases vision may deteriorate so that a person is considered “legally” blind (i.e., vision that is 20/200 or worse). Complete blindness is uncommon in individuals with cone dystrophy.

How long does a full field ERG take?

Pattern ERG provides information mostly about the functioning of neurons in the inner retina (e.g. ganglion cells, etc.). How to prepare for the ERG test? The full-field ERG test lasts about one and a half hours; the pattern ERG test lasts about one hour.

What is a transcription factor for dummies?

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.

Do NOT follow this link or you will be banned from the site!