What is usually the first early symptom of multiple myeloma?

Multiple myeloma causes many symptoms, but bone pain often is the first symptom people notice. Other symptoms include: Weakness in your arms and legs and/or a sensation of numbness in your arms and legs. Multiple myeloma can affect the bones in your spine, causing them to collapse and press on your spinal cord.

Does everyone with smoldering myeloma always progress?

Patients with MGUS have a low level of abnormal plasma cells and abnormal protein in their blood. Since patients with smoldering myeloma have even more abnormal plasma cells, they’re more likely to develop multiple myeloma. But MGUS may not ever progress or require treatment.

How fast can smoldering myeloma progress?

We found that the overall risk of progression among patients with smoldering multiple myeloma was approximately 10% per year in the first 5 years and 3% per year in the next 5 years with a decrease to 1% per year thereafter.

Where does myeloma pain start?

Multiple myeloma can cause pain in affected bones – usually the back, ribs or hips. The pain is frequently a persistent dull ache, which may be made worse by movement.

How long can you have myeloma without knowing?

Some people have multiple myeloma for months or years before they even know they’re sick. This earliest phase is called smoldering multiple myeloma. When you have it, you won’t have any symptoms, but your test results will show: At least 10% to 59% of your bone marrow is made up of cancerous plasma cells.

What conditions are mistaken for myeloma?

  • Monoclonal gammopathy.
  • Waldenström macroglobulinemia (WM)
  • Primary amyloidosis.
  • Heavy chain disease.
  • Light chain deposition disease (LCDD)
  • Plasma cell leukemia (PCL)
  • POEMS syndrome.

How do I stop smoldering in myeloma?

  1. Watchful waiting. Experts usually recommend this option for people with low-risk smoldering myeloma.
  2. Chemotherapy. If you’re at high risk for active multiple myeloma, your doctor may prescribe a chemotherapy drug, lenalidomide (Revlimid), with or without dexamethasone.
  3. Immunotherapy.

How fast does light chain myeloma progress?

These patients are regarded as having light-chain smouldering multiple myeloma, and have a cumulative probability of progression to active multiple myeloma or light-chain amyloidosis of 27·8% at 5 years, 44·6% at 10 years, and 56·5% at 15 years.

Is smoldering multiple myeloma hereditary?

Multiple Myeloma is not considered a hereditary disease. While in some cases Multiple Myeloma may occur due to genetic abnormality, there is no evidence that heredity plays any role in its development. Research has shown several factors may contribute towards the development of Multiple Myeloma.

How long can a person live with smoldering myeloma?

“I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr. Hillengass says. Multiple myeloma is a cancer of cells of the immune system which can cause symptoms like holes in the bones (osteolytic lesions), kidney failure, low blood counts and high calcium in the blood.

What is high risk Smouldering myeloma?

Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell dyscrasia with a high propensity to progress to symptomatic myeloma (MM). It meets all the diagnostic criteria for MM, but without lytic bone disease, anemia, renal failure, or hypercalcemia (CRAB symptoms).

What is the difference between MGUS and smoldering multiple myeloma?

MGUS was defined as the presence of serum M-protein

Do you sleep a lot with myeloma?

People living with multiple myeloma can feel extremely tired even if they’re getting enough sleep. This condition is called fatigue. It’s important to recognize the symptoms of fatigue and to report those symptoms to your healthcare team.

Does myeloma affect legs?

Nerve damage: Myeloma proteins can be toxic to your nerves. This can lead to a condition called peripheral neuropathy that causes a pins-and-needles feeling, often in your legs and feet.

Does multiple myeloma affect the bowels?

Conclusions. Multiple myeloma has myriad presentations. Gastrointestinal involvement, although rare, can manifest as small bowel obstruction for which early recognition and appropriate surgical management are key to improving outcome.

Can you have multiple myeloma with normal blood work?

Sometimes, multiple myeloma is found early when a routine blood test shows an abnormally high amount of protein in the blood. People with MGUS (monoclonal gammopathy of unknown significance) or solitary plasmacytoma are at risk of developing multiple myeloma and have regular bloodwork to monitor for it.

Does myeloma affect the brain?

What is it? Myeloma and myeloma treatments can affect the brain’s ability to collect, retain and process information. ‘Chemo brain’ is a term used to describe the mind and memory issues cancer patients can experience. Your healthcare team may refer to these symptoms as cancer-related cognitive changes.

Is myeloma classed as a terminal illness?

Unfortunately, though, myeloma is currently an incurable (terminal) cancer.

What are the red flags for multiple myeloma?

High blood levels of calcium Extreme thirst, leading to drinking a lot. Urinating (peeing) a lot. Dehydration. Kidney problems and even kidney failure.

Can arthritis be mistaken for myeloma?

It happens when myeloma cells damage or thin the bones where they grow. You typically feel it in your back or ribs, but it can affect any bone. Rheumatoid arthritis, which affects the joints of your hands and wrists, might also be mistaken for multiple myeloma.

What is the difference between smoldering myeloma and multiple myeloma?

Smoldering myeloma is a precursor stage of multiple myeloma. Historically, smoldering myeloma patients have not been put on active treatment because many of them only have a 10% risk per year for the first 5 years of progressing to active myeloma (with a cumulative 50% risk).

What is the last stage of myeloma?

In multiple myeloma cases, stage 3 is the terminal stage. This means it’s the most advanced stage of this type of rare cancer. Doctors use the international staging system to determine the stage of the cancer. This system is based on the levels of serum beta-2 microglobulin and serum albumin.

Does multiple myeloma qualify for Social Security disability?

Multiple Myeloma has been determined by the Social Security Administration (SSA) to be one of the diseases which can cause a person to qualify for Social Security Disability benefits.

What are the normal level of light chains in myeloma?

The normal ranges for free light chains are generally: 3.3 to 19.4 milligrams per liter (mg/L) kappa free light chains. 5.71 to 26.3 mg/L lambda free light chains.

What causes free light chains to increase?

If the amount of free light chains is higher or lower than normal, it can mean you have a disorder of the plasma cells. These include multiple myeloma, a cancer of plasma cells, and amyloidosis, a condition that causes a dangerous buildup of proteins in different organs and tissues.

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