In particular, the production of hard aspirin tablets requires only four ingredients: the active ingredient (acetylsalicylic acid), corn starch, water, and a lubricant.
How do you make aspirin in chemistry?
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched with the addition of water.
How is aspirin purified in a lab?
The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2). After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.
What is the purpose of the synthesis of aspirin lab?
Objectives: To synthesize aspirin as economically as possible. To determine the purity and the theoretical and actual % yield, and suggest ways to improve them.
How do you make aspirin in a school lab?
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H2SO4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.
How do I make my own aspirin?
How is aspirin made step by step?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
What is another name for aspirin?
Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects.
Is aspirin made of oil?
It is a common misconception that aspirin is produced from the bark of the willow tree. In fact, the starting material for the chemical synthesis of aspirin is benzene, derived from petroleum.
Why is aspirin dissolved in water?
Aspirin contains polar functional groups which can form hydrogen bonds with polar water molecules. Aspirin is more soluble in basic (alkaline) solutions, so it readily dissolves in the duodenum which is the first part of the intestine.
What happens when aspirin dissolves in water?
Aspirin is a pain reliever and fever reducer, but if it’s allowed to react with water then it can undergo hydrolysis, forming salicylic acid and acetic acid, which is no longer effective. This reaction can occur under acidic or basic conditions.
Why is ethanol used to purify aspirin?
Ethanol has been chosen as the solvent because the polar nature of the hydroxyl group causes ethanol to dissolve many ionic compounds, moreover the ethanol molecule also has a non-polar end, and it will also dissolve non-polar substances. While cooling, crystallization takes place.
What type of reaction is used to make aspirin?
The synthesis of aspirin is known in organic chemistry as an esterification reaction. This is a substitution reaction in which an alcohol (the –OH group in salicylic acid) reacts with acetic anhydride to form an ester, aspirin.
Why is sulfuric acid added to aspirin?
The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid. Aim: To prepare aspirin from salicylic acid.
Why do you wash aspirin with cold water?
The aspirin crystals are collected on a Buchner funnel and washed with additional ice cold distilled water. Acetic anhydride decomposes to water soluble acetic acid. Aspirin has a low solubility in cold water, so excess reactants could be washed away with cold water.
Why does aspirin smell like vinegar?
When acetylsalicylic acid ages, it may decompose and return to salicylic acid and acetic acid. If you have a very old bottle of aspirin around the house, open it and take a sniff. It may smell like vinegar, because vinegar is dilute acetic acid.
How is aspirin prepared 12?
It is obtained by acetylating salicyclic acid with acetic anhydride and conc. H2SO4. Was this answer helpful?
Is aspirin made from willow trees?
It is a common misconception that aspirin is found in the bark of the willow tree. A related compound called salicin does indeed occur in willow bark, thereby explaining the use of the bark as a medication since the time of Hippocrates.
Where does aspirin come from?
History of aspirin It comes from Spiraea, a biological genus of shrubs that includes natural sources of the drug’s key ingredient: salicylic acid. This acid, resembling what’s in modern-day aspirin, can be found in jasmine, beans, peas, clover and certain grasses and trees.
Which trees have salicylic acid?
Salicylic acid (2-hydroxybenzoic acid) is a white solid first isolated from the bark of willow trees (Salix spp.), from which it gets its name.
Is aspirin an acid or base?
Aspirin itself is an acidic medicine and causes gastric irritation and regurgitation which can lead to low oral pH levels [7].
What class is aspirin?
Aspirin, an acetylated salicylate (acetylsalicylic acid), is classified among the nonsteroidal antiinflammatory drugs (NSAIDs).
Who discovered aspirin?
In 1897, Felix Hoffman, a German chemist working for the Bayer company, was able to modify salicylic acid to create acetylsalicylic acid, which was named aspirin (Fig. 1).
Is aspirin good for pain?
Aspirin is an everyday painkiller for aches and pains such as headache, toothache and period pain. It can also be used to treat colds and flu-like symptoms, and to bring down a high temperature. Aspirin is known as an acetylsalicylic acid.
Is aspirin a natural?
Yet, while aspirin has been one of the most popular pharmaceutical agents of the past one hundred years, it is actually a synthetic derivative of the natural substance salicylic acid—the associated healing properties of which have been known for millennia.